Protein name:
Latent-transforming growth factor beta-binding protein 4 (LTBP-4) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. Interacts with LTBP1 AND TGFB1. Binds to FBN1.
Function:
May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MRRPGLGGPC | PLLLLLLLPA | ATSASGSSPS | PSPSPIEKAV | VPSHQAGVAA |
100:
CHCCLDQTPK | SSRCTRASCR | VRNCPPAKCT | GLEGCLTPTP | SVPSPSRSPV |
150:
EKSQVSLNWQ | PLTLQEARAL | LRQRRPRGPW | ARALLKRRPP | HRAPAGQARV |
200:
LCPLICHNGG | VCVKPDRCLC | PPDFAGKFCQ | LHSSGARPPA | PAMPGLTRSV |
250:
YTMPLANHRD | DEHGVASMVS | VHVEHPQEAS | VVVHQVERVS | GPWEEANPEA |
300:
LARAEAAARA | EAAAPYTVLA | QSAPREDGYS | DASGFGYCFR | ELRGSECASP |
350:
LPGLRTQEVC | CRGEGLAWGV | HDCHPCAEHL | RNSNQVSGPN | GPCPPGFERV |
400:
NGSCVDVDEC | ATGGRCQHGE | CANTRGGYTC | VCPDGFLLDS | SRSSCISQHV |
450:
ISEAKGPCYR | VLHDGGCSLP | ILRNITKQIC | CCSRVGKAWG | RGCQLCPPYG |
500:
SEGFREICPA | GPGYHYSASD | LRYNTRPLNQ | DPPRVTFNQP | RVPPATPRPP |
550:
TGFLPTRRPE | PRPDPGPQPE | PRPRPEPRPR | PESRPRPEPR | PRPEPRPQPE |
600:
SQPRPESRPR | PESQPWPEFP | LPSIPAWTGP | EIPESGPSSS | MCQRNPQVCG |
650:
PGRCVPRPSG | YTCACDPGFR | LGPQGTRCID | IDECRRVPTP | CAPGRCENTP |
700:
GSFRCVCGTG | FQAGPRATEC | LDVDECRRVP | PPCDRGRCEN | TPGSFLCVCP |
750:
AGYQAAPHGA | SCQDVDECTQ | SPGLCGRGVC | ENLPGSFRCV | CPAGFRGSAC |
800:
EEDVDECAQQ | PPPCGPGRCD | NTAGSFHCAC | PAGFRSRGPG | APCQDVDECS |
850:
RSPSPCAYGR | CENTEGSFKC | VCPTGFQPNA | AGSECEDVDE | CENRLACPGQ |
900:
ECVNSPGSFQ | CRACPVGHHL | HRGRCTDVDE | CSSGTPCGLH | GQCTNTKGSF |
950:
HCSCSTGYRA | PSGQPGPCAD | INECLEGDFC | FPHGECLNTD | GSFTCTCAPG |
1000:
YRPGPRGASC | LDVDECSEED | LCQSGICTNT | DGSFECICPP | GHRAGPDLAS |
1050:
CLDIDECRER | GPALCGSQRC | ENSPGSYRCV | RDCDPGYHPG | PEGTCDDIDE |
1100:
CREYGSAICG | AQRCENTPGS | YRCTPACDPG | YQPTPGGGCQ | DVDECRNRSF |
1150:
CGAHAMCQNL | PGSFQCVCDQ | GYEGARDGRH | CVDVNECETL | QGVCGSALCE |
1200:
NVEGSFLCVC | PNSPEEFDPM | TGRCVPPRAP | AGTFPGSQPQ | APASPSLPAR |
1250:
PPAPPPPRRP | SPPRQGPVSS | GRRECYFDTA | APDACDNILA | RNVTWQECCC |
1300:
TVGEGWGSGC | RIQQCPGTET | AEYQSLCPHG | RGYLVPSGDL | SARRDVDECQ |
1350:
LFQDQVCKSG | VCVNTAPGYS | CYCSNGFYYH | AHRLECVDND | ECADEEPACE |
1400:
GGRCVNTVGS | YHCTCEPPLV | LDGSRRRCVS | NESQSLDDNL | GVCWQEVGPD |
1450:
LVCSRPRLDR | QATYTECCCL | YGEAWGMDCA | LCPAQDSDDF | EALCNVLRPP |
1500:
AYGPPRPGGF | GIPYEYGPDI | GPPYQSLPYG | PDLYPPPVLP | YDPYPPPPGP |
1550:
FARREAPYGA | PPFDMPDFED | DGGPYGESET | PDPPSRGTGW | PYRSRDTRGS |
1600:
FPEPEESSER | GSYTGALSEP | YEGLEAEECG | ILDGCPHGRC | VRVPEGFTCD |
1650:
CFDGYRLDIT | RMSCVDVNEC | DEAEATSPLC | VNARCVNTDG | SFRCICRPGF |
1666:
APTHQPHHCA | PARPRA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse LTBP-4
ELISA Kit for Mouse LTBP-4
CLIA Kit for Mouse LTBP-4
CLIA Kit for Mouse LTBP-4
Polyclonal Antibody for Mouse LTBP-4
Polyclonal Antibody for Mouse LTBP-4
Monoclonal Antibody for Mouse LTBP-4
Monoclonal Antibody for Mouse LTBP-4
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
"Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer."
Sterner-Kock A.
,
Thorey I.S.
,
Koli K.
,
Wempe F.
,
Otte J.
,
Bangsow T.
,
Kuhlmeier K.
,
Kirchner T.
,
Jin S.
,
Keski-Oja J.
,
von Melchner H.
Genes Dev.16:2264-2273(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);DISRUPTION PHENOTYPE
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-1666 (ISOFORM 3)
strain :
C57BL/6 .
tissue :
Brain .
4.
"Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development."
Urban Z.
,
Hucthagowder V.
,
Schuermann N.
,
Todorovic V.
,
Zilberberg L.
,
Choi J.
,
Sens C.
,
Brown C.W.
,
Clark R.D.
,
Holland K.E.
,
Marble M.
,
Sakai L.Y.
,
Dabovic B.
,
Rifkin D.B.
,
Davis E.C.
Am. J. Hum. Genet.85:593-605(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE